LOCUS P02834 389 aa linear INV 15-JUN-2004 DEFINITION Homeotic Ultrabithorax protein. ACCESSION P02834 VERSION P02834 GI:729749 DBSOURCE swissprot: locus HMUX_DROME, accession P02834; class: standard. extra accessions:Q9TX83,Q9VER4,Q9VER5 created: Jul 21, 1986. sequence updated: Feb 1, 1995. annotation updated: Jun 15, 2004. xrefs: X05723.1, CAA29194.1, X05724.1, X05725.1, X05727.1, X76210.1, CAA53803.1, U31961.1, AAA84412.1, AAA84411.1, AAA84410.1, AAA84409.1, AAA84408.1, AE003714.2, AAF55355.2, AAF55356.1, AAN13717.1, AAN13718.1, AAN13719.1, BT010241.1, AAQ23559.1, K01963.1, AAA29008.1, K01959.1, AAA28615.1, X05427.1, CAA29009.1, AF099983.1, AAD16402.1, AF099980.1, AF099981.1, AF099982.1, B27867, D26995, 1B8I xrefs (non-sequence databases): TRANSFAC:T00863, FlyBase:FBgn0014820, FlyBase:FBgn0003944, GO:0005634, GO:0003677, GO:0007482, GO:0007501, GO:0045449, GO:0010092, GO:0007384, InterPro:IPR001827, InterPro:IPR001356, Pfam:PF00046, PRINTS:PR00025, PRINTS:PR00024, ProDom:PD000010, PROSITE:PS00032, PROSITE:PS00027, PROSITE:PS50071 KEYWORDS Transcription regulation; Activator; Repressor; Homeobox; DNA-binding; Developmental protein; Nuclear protein; Alternative splicing; 3D-structure. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila. REFERENCE 1 (residues 1 to 389) AUTHORS Weinzierl,R., Axton,J.M., Ghysen,A. and Akam,M. TITLE Ultrabithorax mutations in constant and variable regions of the protein coding sequence JOURNAL Genes Dev. 1, 386-397 (1987) REMARK SEQUENCE FROM N.A. (ISOFORM IB). SPECIES=D.melanogaster; STRAIN=Canton-S REFERENCE 2 (residues 1 to 389) AUTHORS Kornfeld,K., Saint,R.B., Beachy,P.A., Harte,P.J., Peattie,D.A. and Hogness,D.S. TITLE Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila JOURNAL Genes Dev. 3 (2), 243-258 (1989) PUBMED 2565858 REMARK SEQUENCE FROM N.A. (ISOFORMS IA; IB; IIA; IIB; IVA AND IVB). SPECIES=D.melanogaster REFERENCE 3 (residues 1 to 389) AUTHORS Martin,C.H., Mayeda,C.A., Davis,C.A., Ericsson,C.L., Knafels,J.D., Mathog,D.R., Celniker,S.E., Lewis,E.B. and Palazzolo,M.J. TITLE Complete sequence of the bithorax complex of Drosophila JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (18), 8398-8402 (1995) PUBMED 7667301 REMARK SEQUENCE FROM N.A. (ISOFORMS IA; IB; IIA; IIB AND IVA). SPECIES=D.melanogaster; STRAIN=Canton-S REFERENCE 4 (residues 1 to 389) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REMARK SEQUENCE FROM N.A. SPECIES=D.melanogaster; STRAIN=Berkeley REFERENCE 5 (residues 1 to 389) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol. 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REMARK REVISIONS, AND ALTERNATIVE SPLICING. SPECIES=D.melanogaster; STRAIN=Berkeley REFERENCE 6 (residues 1 to 389) AUTHORS Stapleton,M., Brokstein,P., Hong,L., Agbayani,A., Carlson,J.W., Champe,M., Chavez,C., Dorsett,V., Dresnek,D., Farfan,D., Frise,E., George,R.A., Gonzalez,M., Guarin,H., Kronmiller,B., Li,P.W., Liao,G., Miranda,A., Mungall,C.J., Nunoo,J., Pacleb,J.M., Paragas,V., Park,S., Patel,S., Phouanenavong,S., Wan,K.H., Yu,C., Lewis,S.E., Rubin,G.M. and Celniker,S.E. TITLE Direct Submission JOURNAL Submitted (??-AUG-2003) REMARK SEQUENCE FROM N.A. (ISOFORM IA). SPECIES=D.melanogaster; STRAIN=Berkeley; TISSUE=Embryo REFERENCE 7 (residues 1 to 389) AUTHORS McGinnis,W., Garber,R.L., Wirz,J., Kuroiwa,A. and Gehring,W.J. TITLE A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans JOURNAL Cell 37 (2), 403-408 (1984) PUBMED 6327065 REMARK SEQUENCE OF 290-389 FROM N.A. SPECIES=D.melanogaster REFERENCE 8 (residues 1 to 389) AUTHORS Scott,M.P. and Weiner,A.J. TITLE Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila JOURNAL Proc. Natl. Acad. Sci. U.S.A. 81 (13), 4115-4119 (1984) PUBMED 6330741 REMARK SEQUENCE OF 290-384 FROM N.A. SPECIES=D.melanogaster REFERENCE 9 (residues 1 to 389) AUTHORS Chan,S.K. and Mann,R.S. TITLE The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences JOURNAL Genes Dev. 7 (5), 796-811 (1993) PUBMED 8098307 REMARK SEQUENCE OF 294-355 FROM N.A. SPECIES=D.melanogaster REFERENCE 10 (residues 1 to 389) AUTHORS Saari,G. and Bienz,M. TITLE The structure of the ultrabithorax promoter of Drosophila melanogaster JOURNAL EMBO J. 6, 1775-1779 (1987) REMARK SEQUENCE OF 1-8 FROM N.A. SPECIES=D.melanogaster REFERENCE 11 (residues 1 to 389) AUTHORS Stern,D.L. TITLE A role of Ultrabithorax in morphological differences between Drosophila species JOURNAL Nature 396 (6710), 463-466 (1998) PUBMED 9853753 REMARK SEQUENCE FROM N.A. (ISOFORM IB). SPECIES=D.simulans; STRAIN=Tsimbazaza REFERENCE 12 (residues 1 to 389) AUTHORS Ekker,S.C., Young,K.E., von Kessler,D.P. and Beachy,P.A. TITLE Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila JOURNAL EMBO J. 10 (5), 1179-1186 (1991) PUBMED 1673656 REMARK DNA-BINDING. SPECIES=D.melanogaster REFERENCE 13 (residues 1 to 389) AUTHORS Bomze,H.M. and Lopez,A.J. TITLE Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila JOURNAL Genetics 136 (3), 965-977 (1994) PUBMED 7911773 REMARK ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY. SPECIES=D.melanogaster; STRAIN=Oregon-R; TISSUE=Embryo REFERENCE 14 (residues 1 to 389) AUTHORS Passner,J.M., Ryoo,H.D., Shen,L., Mann,R.S. and Aggarwal,A.K. TITLE Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex JOURNAL Nature 397 (6721), 714-719 (1999) PUBMED 10067897 REMARK X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 233-356 IN COMPLEX WITH EXD. SPECIES=D.melanogaster COMMENT On Mar 25, 1995 this sequence version replaced gi:123429. ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [FUNCTION] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor. [SUBCELLULAR LOCATION] Nuclear. [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=6; Name=IB; IsoId=P02834-1; Sequence=Displayed; Note=Has been shown to exist only in D.simulans so far; Name=IA; IsoId=P02834-2; Sequence=VSP_002405; Name=IIA; IsoId=P02834-3; Sequence=VSP_002406; Name=IIB; IsoId=P02834-4; Sequence=VSP_002408; Name=IVA; IsoId=P02834-5; Sequence=VSP_002407; Name=IVB; IsoId=P02834-6; Sequence=VSP_002409. [TISSUE SPECIFICITY] In the embryo, expression is seen in the epidermis, somatic and visceral mesoderm, and the peripheral and central nervous system. [DOMAIN] The QA domain is able to mediate transcriptional repression (By similarity). [SIMILARITY] Belongs to the Antp homeobox family. [SIMILARITY] Contains 1 homeobox domain. FEATURES Location/Qualifiers source 1..389 /organism="Drosophila melanogaster" /db_xref="taxon:7227" source 1..389 /organism="Drosophila simulans" /db_xref="taxon:7240" gene 1..389 /gene="UBX" /note="synonym: CG10388" Protein 1..389 /gene="UBX" /product="Homeotic Ultrabithorax protein" Region 33..39 /gene="UBX" /region_name="Domain" /experiment="experimental evidence, no additional details recorded" /note="Poly-Ala." Region 75 /gene="UBX" /region_name="Conflict" /experiment="experimental evidence, no additional details recorded" /note="N -> Y (in Ref. 3)." Region 111..129 /gene="UBX" /region_name="Domain" /experiment="experimental evidence, no additional details recorded" /note="Poly-Gly." Site 239..244 /gene="UBX" /site_type="unclassified" /experiment="experimental evidence, no additional details recorded" /note="Antp-type hexapeptide." Region 248..290 /gene="UBX" /region_name="Splicing variant" /experiment="experimental evidence, no additional details recorded" /note="Missing (in isoform IVA). /FTId=VSP_002407." Region 248..273 /gene="UBX" /region_name="Splicing variant" /experiment="experimental evidence, no additional details recorded" /note="Missing (in isoform IIA). /FTId=VSP_002406." Region 248..256 /gene="UBX" /region_name="Splicing variant" /experiment="experimental evidence, no additional details recorded" /note="Missing (in isoform IA). /FTId=VSP_002405." Region 257..290 /gene="UBX" /region_name="Splicing variant" /experiment="experimental evidence, no additional details recorded" /note="Missing (in isoform IVB). /FTId=VSP_002409." Region 258..274 /gene="UBX" /region_name="Splicing variant" /experiment="experimental evidence, no additional details recorded" /note="Missing (in isoform IIB). /FTId=VSP_002408." Site 295..354 /gene="UBX" /site_type="DNA binding" /experiment="experimental evidence, no additional details recorded" /note="Homeobox." Region 304..316 /gene="UBX" /region_name="Helical region" /experiment="experimental evidence, no additional details recorded" Region <309..353 /gene="UBX" /region_name="homeodomain" /note="Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; cd00086" /db_xref="CDD:28970" Region 322..332 /gene="UBX" /region_name="Helical region" /experiment="experimental evidence, no additional details recorded" Region 322..325 /gene="UBX" /region_name="Domain" /experiment="experimental evidence, no additional details recorded" /note="Poly-Arg." Region 330 /gene="UBX" /region_name="Conflict" /experiment="experimental evidence, no additional details recorded" /note="H -> Y (in Ref. 7)." Region 333 /gene="UBX" /region_name="Hydrogen bonded turn" /experiment="experimental evidence, no additional details recorded" Region 336..351 /gene="UBX" /region_name="Helical region" /experiment="experimental evidence, no additional details recorded" Region 340 /gene="UBX" /region_name="Conflict" /experiment="experimental evidence, no additional details recorded" /note="K -> E (in Ref. 7)." Region 352..353 /gene="UBX" /region_name="Hydrogen bonded turn" /experiment="experimental evidence, no additional details recorded" Site 368..383 /gene="UBX" /site_type="unclassified" /experiment="experimental evidence, no additional details recorded" /note="QA." ORIGIN 1 mnsyfeqasg fyghphqatg mamgsgghhd qtasaaaaay rgfplslgms pyanhhlqrt 61 tqdspydasi taacnkiygd gagaykqdcl nikadavngy kdiwntggsn gggggggggg 121 gggaggtgga gnanggnaan angqnnpagg mpvrpsactp dsrvggyldt sggspvshrg 181 gsaggnvsvs ggngnaggvq sgvgvagagt awnanctisg aaaqtaaass lhqasnhtfy 241 pwmaiagecp edptkskirs dltqyggist dmgkrysesl agsllpdwlg tnglrrrgrq 301 tytryqtlel ekefhtnhyl trrrriemah alclterqik iwfqnrrmkl kkeiqaikel 361 neqekqaqaq kaaaaaaaaa avqgghldq //
Feb 20 2007 16:53:14